DNA/RNA Synthesis

Related Products

RNA synthesis, which is also called DNA transcription, is a highly selective process. Transcription by RNA polymerase II extends beyond RNA synthesis, towards a more active role in mRNA maturation, surveillance and export to the cytoplasm.

Single-strand breaks are repaired by DNA ligase using the complementary strand of the double helix as a template, with DNA ligase creating the final phosphodiester bond to fully repair the DNA.DNA ligases discriminate against substrates containing RNA strands or mismatched base pairs at positions near the ends of the nickedDNA. Bleomycin (BLM) exerts its genotoxicity by generating free radicals, whichattack C-4′ in the deoxyribose backbone of DNA, leading to opening of the ribose ring and strand breakage; it is an S-independentradiomimetic agent that causes double-strand breaks in DNA.

First strand cDNA is synthesized using random hexamer primers and M-MuLV Reverse Transcriptase (RNase H). Second strand cDNA synthesis is subsequently performed using DNA Polymerase I and RNase H. The remaining overhangs are converted into blunt ends using exonuclease/polymerase activity. After adenylation of the 3′ ends of DNA fragments, NEBNext Adaptor with hairpin loop structure is ligated to prepare the samples for hybridization. Cell cycle and DNA replication are the top two pathways regulated by BET bromodomain inhibition. Cycloheximide blocks the translation of mRNA to protein.

DNA/RNA Synthesis Related Products (1675)
Antibodies (247)

By Effects:	Controls (5) Ligand (1) Inhibitors (942) Substrate (1) Agonists (7) Degrader (1) Antagonists (2) Activators (28) Modulators (24) Chemicals (19) Inducers (7)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-109101S

Risdiplam-d₄		98.88%
Risdiplam-d₄ is deuterium labeled Risdiplam. Risdiplam (RG7916) is an orally administered, centrally and peripherally distributed SMN2 pre-mRNA splicing modifier that increases survival motor neuron (SMN) protein levels.

HY-136559

6-Azathymine	Inhibitor	99.94%
6-Azathymine, a 6-nitrogen analog of thymine, is a potent D-3-aminoisobutyrate-pyruvate aminotransferase inhibitor. 6-Azathymine inhibits the biosynthesis of DNA, and has antibacterial and antiviral activities.

HY-139038

TDRL-X80		99.6%
TDRL-X80 is a potent inhibitor of xeroderma pigmentosum group A (XPA) protein. TDRL-X80 inhibits XPA’s DNA binding activity. TDRL-X80 exhibits activity against single, double, and Cisplatin-damaged DNA with IC₅₀s of 18, 20, and 29 μM in fluorescence polarization (FP) analyses , and with IC₅₀s of 21, 39, and 28 in ELISA Analysis.

HY-16445B

CNDAC hydrochloride	Inhibitor	99.59%
CNDAC hydrochloride is a metabolite of the orally active agent Sapacitabine (HY-16445), and a nucleoside analog. CNDAC hydrochloride induces DNA damage and apoptosis.

HY-145330

NSC639828	Inhibitor	99.91%
NSC639828 is a potent inhibitor of DNA polymerase α with an IC₅₀ of 70 μM. NSC639828 has high antitumor activity. NSC639828 has the potential for researching cancer disease.

HY-138645A

5-Iminodaunorubicin hydrochloride	Inhibitor
5-Iminodaunorubicin hydrochloride is a quinone-modified anthracycline that retains antitumor activity. 5-Iminodaunorubicin hydrochloride produces protein-concealed DNA strand breaks in cancer cells.

HY-W010820

Uridine 5'-diphosphate sodium salt	Activator	≥98.0%
Uridine 5'-diphosphate sodium salt is a potent, selective P2Y₆ receptor native agonist (EC₅₀=300 nM; pEC₅₀=6.52) and a potent P2Y₁₄ antagonist (pEC₅₀=7.28). Uridine 5'-diphosphate sodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis.

HY-138589

7-TFA-ap-7-Deaza-dG		98.04%
5'-O-TBDMS-dG is a modified nucleoside. 5'-O-DMT-2'-O-TBDMS-rI can be used in the synthesis of deoxyribonucleic acid or nucleic acid. 7-TFA-ap-7-Deaza-dG is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-W040795

N2-Acetylguanine		99.69%
N2-Acetylguanine is a C2-modified guanine. N2-Acetylguanine binds GR (guanine-guanine riboswitch) with an K_d value of 300 nM. N2-Acetylguanine modulate transcriptional termination. N2-Acetylguanine has the potential for the research of antimicrobial agent.

HY-B2067

Cymoxanil	Inhibitor	99.55%
Cymoxanil is a fungicidal cyanooxime against plant diseases caused by fungi belonging to the Perenosporales. Cymoxanil affects growth, DNA and RNA synthesis in Phytophthora.

HY-162457

Mn007
Mn007 is a potent inhibitor of bovine pancreatic DNase I, with the IC₅₀ of 45 μM, by forming molecular aggregation. Mn007 shows suppression of S. pyogenes growth in human whole blood.

HY-122604

PF-DcpSi		≥98.0%
PF-DcpSi is a mRNA decapping scavenger enzyme (DcpS) inhibitor (IC₅₀: 0.11 nM). PF-DcpSi (30 mg/kg,i.p.) ameliorates the disease phenotype in a mice model of spinal muscular atrophy (SMA).

HY-101400S3

Deoxycytidine triphosphate-¹⁵N₃ dilithium	Activator	≥99.0%
Deoxycytidine triphosphate-¹⁵N₃ (dCTP-¹⁵N₃ dilithium; 2′-Deoxycytidine-5′-triphosphate-¹⁵N₃) dilithium is ¹⁵N labeled Deoxycytidine triphosphate (HY-101400). Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that can be used for DNA synthesis. Deoxycytidine triphosphate has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing.

HY-143412

MIR002	Inhibitor	≥99.0%
MIR002 is a potent and orally active DNA polymerase α (POLA1) and HDAC 11 dual inhibitor. MIR002 induces acetylation of p53, activation of p21, G1/S cell cycle arrest, and apoptosis. MIR002 shows significant antitumor activity in vivo.

HY-W008849

DMT-dC(bz) Phosphoramidite		99.44%
DMT-dC(bz) Phosphoramidite is typically used in the synthesis of DNA.

HY-121834

RNase L-IN-2		98.63%
RNase L-IN-2 (compound 2) is an activtor of RNase L with EC₅₀ value of 22 μM.

HY-131468

Picoplatin	Inhibitor	98.5%
Picoplatin (AMD473) is a platinum-based antineoplastic agent. Picoplatin is specifically to circumvent thiol-mediated drug resistance by sterically hindering its reaction with glutathione (GSH) while still retaining the ability to form cytotoxic lesions with DNA.

HY-135780

3'-Deoxyuridine-5'-triphosphate	Inhibitor
3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II. 3'-Deoxyuridine-5'-triphosphate strongly and competitively inhibits the incorporations of UTP into RNA with a K_i value of 2.0 μM.

HY-W017443S1

L-Asparagine-amide-¹⁵N monohydrate		99.80%
L-Asparagine-amide-¹⁵N monohydrate is the ¹⁵N-labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia.

HY-N6853

Mogroside I E1	Inhibitor	99.11%
Mogroside I E1 is a triterpenoid glycoside and a nonsugar sweetener. Mogrosides are sweeter than sucrose. Mogrosides exhibit antioxidant, antidiabetic and anticancer activities.

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DNA/RNA Synthesis

DNA/RNA Synthesis

DNA/RNA Synthesis Related Products (1675)

Antibodies (247)

DNA/RNA Synthesis Related Products (1675):